Apaf-1 rabbit pAb

Ref. EK-ES4108

Informations sur le produit

• Nom: Apaf-1 rabbit pAb
• Synonymes: APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1

Description

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

• Marque: ELK Biotechnology