PA26 rabbit pAb

Ref. EK-ES5548

Informations sur le produit

• Nom: PA26 rabbit pAb
• Synonymes: SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26

Description

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

• Marque: ELK Biotechnology