Arrestin-β-1 (phospho Ser412) rabbit pAb

Ref. EK-ES6147

Informations sur le produit

• Nom: Arrestin-β-1 (phospho Ser412) rabbit pAb
• Synonymes: ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1

Description

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],

• Marque: ELK Biotechnology