Insulin rabbit pAb

Ref. EK-ES8775

Informations sur le produit

• Nom: Insulin rabbit pAb
• Synonymes: Insulin [Cleaved into: Insulin B chain; Insulin A chain]

Description

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],

• Marque: ELK Biotechnology