TM-L6030 - natural-product-derivatives-library-for-cadd

The Toolbox contains the 20 standard Fmoc-amino acid L-derivatives at 5 g per each vial. These are Fmoc-Ala-OH · H₂O (No. 4003167), Fmoc-Arg(Pbf)-OH (No. 4089151), Fmoc-Asn(Trt)-OH (No. 4014948), Fmoc-Asp(OtBu)-OH (No. 4093142), Fmoc-Cys(Trt)-OH (No. 4007272), Fmoc-Gln(Trt)-OH (No. 4014949), Fmoc-Glu(OtBu)-OH · H₂O (No. 4005951), Fmoc-Gly-OH (No. 4003078), Fmoc-His(1-Trt)-OH (No. 4011444 ), Fmoc-Ile-OH (No. 4003168), Fmoc-Leu-OH (No. 4003139), Fmoc-Lys(Boc)-OH (No. 4003151), Fmoc-Met-OH (No. 4003154), Fmoc-Phe-OH (No. 4100450), Fmoc-Pro-OH (No. 4003150), Fmoc-Ser(tBu)-OH (No. 4003086), Fmoc-Thr(tBu)-OH (No. 4096755), Fmoc-Trp(Boc)-OH (No. 4017674), Fmoc-Tyr(tBu)-OH (No. 4093144), Fmoc-Val-OH (No. 4093145).

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HAND2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HAND2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human HAND2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human HAND2 in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HAND2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HAND2. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human HAND2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human HAND2 in the samples is then determined by comparing the OD of the samples to the standard curve.

Questiomycin A derivatives 14

Questiomycin A derivatives 13

Questiomycin A derivatives 12

Questiomycin A derivatives 18 TFA

Questiomycin A derivatives 20

The library consists of more than 4,000 members belonging 22 scaffolds (average 180 compounds per scaffold).

Calcitriol Derivatives is an analog of vitamin D3.

<p>Applications Oxacyclotetradecane Erythromycin Derivatives is a useful intermediate in the preparation of erythromycin A (E649950) antibiotics and derivatives.<br>References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979), Morimoto, S., et al.: From Eur. Pat. Appl. (1988), EP 272110 A2 19880622,<br></p>

Pentenylglycoside derivatives are synthetic compounds that have a sugar as their core. These compounds are synthesized by glycosylation of pentenyl alcohols with sugars. They are highly soluble in water and have good stability. The molecules have been modified to increase their activity and reduce the toxicity. Some examples of modifications include fluorination, methylation, and click chemistry. This product is not available for sale in the United States because it has not been evaluated by the Food and Drug Administration (FDA).

<p>This kit contains the following products:<br> 100mg of (08-07-1722-100mg) (9R)-10,11-Dihydro-6'-methoxycinchonan-9-amine trihydrochloride, min. 90%<br>100mg of (08-07-1710-100mg) (8α, 9S)-6'-Methoxycinchonan-9-amine trihydrochloride, min. 90%<br>,<br> </p>

Showed the highest inhibitory activity against the T cell line-tropic HIV-1 infection through its specific binding to a chemokine receptor CXCR4 (IC₅₀ = 0.18 ± 0.041 nM) and the strongest inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody to CXCR4 (IC₅₀ = 2.3 ± 0.20 nM).

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family. Its expression in the human central nervous system is altered in neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. BDNF promotes survival of dopaminergic neurons and protects against Aβ-induced neurotoxicity in vitro and in vivo.