SH1573

CAS : 2376068-96-9

Ref. TM-T200209

Informations sur le produit

• Nom: SH1573
• Marque: Targetmol
• Description: SH1573 is an orally active inhibitor of mutant isocitrate dehydrogenase 2 (mIDH2). It selectively targets the mIDH2 R140Q protein with a potent inhibitory effect (IC50=4.78 nmol/L), significantly reducing the production of the oncogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum, and tumors. SH1573 is utilized in the study of acute myeloid leukemia (AML).

Propriétés chimiques

• Masse moléculaire: 635.46
• Formule: C₂₁H₁₈F₉N₇O₄S
• Couleur/Forme: Solid