Nitric oxide production-IN-2

CAS : 1019984-44-1

Ref. TM-T206206

Informations sur le produit

• Nom: Nitric oxide production-IN-2
• Marque: Targetmol
• Description: TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 µM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.

Propriétés chimiques

• Masse moléculaire: 344.403
• Formule: C₂₃H₂₀O₃
• Couleur/Forme: Solid