Nolatrexed dihydrochloride

CAS : 152946-68-4

Ref. TM-T2627

Informations sur le produit

• Nom: Nolatrexed dihydrochloride
• Synonymes: Thymitaq, AG 337, 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride, 3,4-Dihydro-2-Amino-6-Methyl-4-Oxo-5-(4-Pyridylthio)-Quinazoline Dihydrochloride, 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, dihydrochloride, 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, hydrochloride (1:2), Ag 337, Nolatrexed 2Hcl, Nolatrexed Hcl, Thymitaq
• CAS: 152946-68-4

Description

Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 357.26
• Formule: C₁₄H₁₄Cl₂N₄OS
• Degré de pureté: 97.02%
• Couleur/Forme: Tan Solid