5-Hydroxy-1-methylhydantoin
CAS : 84210-26-4
Ref. TM-T28222
1mg | 143,00 € | ||
5mg | 313,00 € | ||
10mg | 460,00 € | ||
25mg | 736,00 € | ||
50mg | 1.046,00 € | ||
100mg | 1.391,00 € | ||
500mg | 2.767,00 € | ||
1ml*10 (DMSO) | 217,00 € |
Informations sur le produit
- HD-003, HD003, NZ419, NZ-419, HD 003, NZ 419
5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.
Propriétés chimiques
Question d’ordre technique sur : TM-T28222 5-Hydroxy-1-methylhydantoin
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