Jervine

CAS : 469-59-0

Ref. TM-T3363

Informations sur le produit

• Nom: Jervine
• Synonymes: Iervin, 11-Ketocyclopamine, Jerwiny, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-Hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, (3beta,22S,23R)-3-hydroxy-17,23-epoxyveratraman-11-one, 17,23beta-Epoxy-3beta-hydroxyveratraman-11-one, Brn 0059109, Hsdb 3502, Iervin, Jervin, Jerwiny, Nsc 23898, Nsc 7520, Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)-pyridin)-11(1H)-one, 2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy- 3',6',10,11b-tetramethyl-, Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)-pyridin)-11(1H)-one, 2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10, 11B-tetramethyl-, Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-, (2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-, Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one, 2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-, [3S-(3α,6aα,6bβ,9α(3′S*,3′aR*,6′R*,7′aS*),11aβ,11bα)]-, Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3-beta,23-beta)-, Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3beta,23beta)-, Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-
• CAS: 469-59-0

Description

The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 425.6
• Formule: C₂₇H₃₉NO₃
• Degré de pureté: 99.86%
• Couleur/Forme: Needles From Methanol + Water Solid