(E)-Guggulsterone

CAS : 39025-24-6

Ref. TM-T36563

Informations sur le produit

• Nom: (E)-Guggulsterone
• Synonymes: (-)-(E)-Guggulsterone, (17E)-Pregna-4,17(20)-diene-3,16-dione, (17E)-pregna-4,17-diene-3,16-dione, 4,17(20)-(trans)-Pregnadiene-3,16-dione, E-Guggulsteron, Guggulsterone E, trans-Guggulsterone

Description

Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR bothin vitroandin vivo.4Thecisstereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50value of 15 μM.5,6By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.4

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 312.45
• Formule: C₂₁H₂₈O₂