DOPAL

CAS : 5707-55-1

Ref. TM-T37533

Informations sur le produit

• Nom: DOPAL
• Synonymes: 2-(3,4-Dihydroxyphenyl)acetaldehyde, 3,4-Dihydroxy-α-tolualdehyde, 3,4-Dihydroxybenzeneacetaldehyde, Acetaldehyde, (3,4-dihydroxyphenyl)-, Benzeneacetaldehyde, 3,4-Dihydroxy-, Dopal, Homoprotocatechualdehyde

Description

DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.[4]

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 152.15
• Formule: C₈H₈O₃