RO1138452

CAS : 221529-58-4

Ref. TM-T4436

Informations sur le produit

• Nom: RO1138452
• Synonymes: CAY10441, Cay 10441, Ro 1138452

Description

RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 309.41
• Formule: C₁₉H₂₃N₃O
• Degré de pureté: 99.34%
• Couleur/Forme: Solid