MMRi62

CAS : 352693-80-2

Ref. TM-T60202

Informations sur le produit

• Nom: MMRi62
• Synonymes: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
• CAS: 352693-80-2

Description

MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 396.27
• Formule: C₂₁H₁₅Cl₂N₃O
• Degré de pureté: 99.7%
• Couleur/Forme: Soild