Flavokawain B

CAS : 1775-97-9

Ref. TM-T6S0735

Informations sur le produit

• Nom: Flavokawain B
• Synonymes: Flavokavain B, Flavokawin B, 2'-Hydroxy-4',6'-Dimethoxychalcone, (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one, (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one, (E)-1-(2-Hydroxy-4,6-Dimethoxy-Phenyl)-3-Phenyl-Propenone, (E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-, (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one, (E)-2′-Hydroxy-4′,6′-dimethoxychalcone, 1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-Phenyl-2-Propen-1-One), 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-, 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-, Cardamonin-4'-Methyl Ether, Chalcone, 2′-hydroxy-4′,6′-dimethoxy-, Dimethoxy-2'-Hydroxychalcone, 4',6'-, Flavokavain B, Flavokavin B, Flavokawin B, Persicochalcone
• CAS: 1775-97-9

Description

1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 284.31
• Formule: C₁₇H₁₆O₄
• Degré de pureté: 100%
• Couleur/Forme: Solid