ALK-1 Protein, Mouse, Recombinant (hFc)

Ref. TM-TMPJ-00304

Informations sur le produit

• Nom: ALK-1 Protein, Mouse, Recombinant (hFc)
• Synonymes: TSR-I, Serine/threonine-protein kinase receptor R3, ALK-1, SKR3, activin A receptor, activin A receptor type II-like 1, TGF-B superfamily receptor type I, Activin receptor-like kinase 1, ACVRL1

Description

Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 55-60 KDa (reducing condition)
• Couleur/Forme: Solid