B7-1 Protein, Cynomolgus, Recombinant (hFc)

Ref. TM-TMPJ-00630

Informations sur le produit

• Nom: B7-1 Protein, Cynomolgus, Recombinant (hFc)
• Synonymes: B7, CD80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen

Description

Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 70-90 KDa (reducing condition)
• Couleur/Forme: Solid