SCF Protein, Rat, Recombinant (HEK293, His)

Ref. TM-TMPJ-00895

Informations sur le produit

• Nom: SCF Protein, Rat, Recombinant (HEK293, His)
• Synonymes: steel factor, Mast cell growth factor, SLF, MGFSHEP7, SCFStem cell factor, SFc-Kit ligand, KL-1, KITLG, SCF, Kitl, MGF, KIT ligand, FPH2

Description

SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 23-40 KDa (reducing condition)
• Couleur/Forme: Solid