WISP1/CCN4 Protein, Mouse, Recombinant (His)

Ref. TM-TMPK-00732

Informations sur le produit

• Nom: WISP1/CCN4 Protein, Mouse, Recombinant (His)
• Synonymes: ELM-1, WISP1tc, WISP1c, CCN4, WISP-1, WISP1i

Description

The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 39.4 kDa (predicted). Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result.
• Couleur/Forme: Solid