Harzianopyridone

CAS : 137813-88-8

Ref. TM-TN7266

Informations sur le produit

• Nom: Harzianopyridone
• Synonymes: 4-Hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexen-1-yl]-2(1H)-pyridinone, 2(1H)-Pyridinone, 4-hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexen-1-yl]-, 2(1H)-Pyridinone, 4-hydroxy-5,6-dimethoxy-3-[(2S,4E)-2-methyl-1-oxo-4-hexenyl]-, (-)-Harzianopyridone

Description

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 281.308
• Formule: C₁₄H₁₉NO₅
• Couleur/Forme: Liquid