Cyclo(L-Leu-L-Trp)

CAS : 15136-34-2

Ref. TM-TP2515

Informations sur le produit

• Nom: Cyclo(L-Leu-L-Trp)
• Synonymes: Cyclo(leu-trp), 2,5-Piperazinedione, 3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)-, (3S-cis)-, 2,5-Piperazinedione, 3-(indol-3-ylmethyl)-6-isobutyl-, (3S,6S)-3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)piperazine-2,5-dione

Description

Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite initially derived from Penicillium, exhibiting antibacterial (MICs = 125-1000 µg/ml) and antifungal activities (MICs = 8-64 µg/ml). It also demonstrates antioxidant properties by reducing the production of hydroxy radicals, as evidenced in an electron spin resonance (ESR) spectroscopy assay (IC50 = 1.8 µM). Additionally, Cyclo(L-Leu-L-Trp) has been identified as a bitter compound capable of quickly crossing rat taste cell membranes ex vivo at a 1 mM concentration. Furthermore, it acts as a melatonin receptor agonist in X. laevis melanophores, suppressing cAMP accumulation at a 20 µM concentration, with this effect being negated by the melatonin receptor antagonist luzindole.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 299.374
• Formule: C₁₇H₂₁N₃O₂
• Couleur/Forme: Solid