1-Acetyl-4-(4-hydroxyphenyl)piperazine

CAS : 67914-60-7

Ref. TR-A179045

Informations sur le produit

• Nom: 1-Acetyl-4-(4-hydroxyphenyl)piperazine
• Synonymes: 1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone, 4-(4-Acetylpiperazino)phenol, 1-Acetyl-4-(p-hydroxyphenyl)piperazine, Ketoconazole Intermediate (branched chain of ketoconazole), 1-Acetyl-4-(4hydroxyphenyl)piperazine, 1-[4-(4-Hydroxyphenyl)Piperazin-1-Yl]Ethanone, 1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethan-1-one, 4-(1-Acetylpiperazin-4-yl)phenol, 4-(4-Acetyl-1-piperazino)phenol, 4-(4-Acetylpiperazin-1-yl)phenol, 4-(4-Acetylpiperazin-4-Yl)Phenol, Ethanone, 1-[4-(4-hydroxyphenyl)-1-piperazinyl]-, Piperazine, 1-acetyl-4-(4-hydroxyphenyl)-, T 1141, Tetraethoxy C methyl propane

Description

Applications 1-Acetyl-4-(4-hydroxyphenyl)piperazine is an intermediate used to prepare Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo.
References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 220.27
• Formule: C₁₂H₁₆N₂O₂
• Couleur/Forme: White
• InChI: InChI=1S/C12H16N2O2/c1-10(15)13-6-8-14(9-7-13)11-2-4-12(16)5-3-11/h2-5,16H,6-9H2,1H3
• Code InChI: InChIKey=AGVNLFCRZULMKK-UHFFFAOYSA-N
• SMILES: CC(=O)N1CCN(c2ccc(O)cc2)CC1