N-(Aminocarbonyl)-3-hydroxy-α-methyl-L-tyrosine

CAS : 43197-06-4

Ref. TR-A602825

Informations sur le produit

• Nom: N-(Aminocarbonyl)-3-hydroxy-α-methyl-L-tyrosine

Description

Applications N-(Aminocarbonyl)-3-hydroxy-α-methyl-L-tyrosine is an intermediate used in the synthesis of (S)-(-)-Carbidopa (C178985), which is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.
References Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 254.24
• Formule: C₁₁H₁₄N₂O₅
• Couleur/Forme: Neat
• InChI: InChI=1S/C11H14N2O5/c1-11(9(16)17,13-10(12)18)5-6-2-3-7(14)8(15)4-6/h2-4,14-15H,5H2,1H3,(H,16,17)(H3,12,13,18)/t11-/m0/s1
• Code InChI: InChIKey=VXDGAWHKWZTBEQ-NSHDSACASA-N
• SMILES: C[C@@](Cc1ccc(O)c(O)c1)(NC(N)=O)C(=O)O