Des-(4-(dimethylamino)-2-butenoyl)-Neratinib

CAS : 848139-78-6

Ref. TR-A604050

Informations sur le produit

• Nom: Des-(4-(dimethylamino)-2-butenoyl)-Neratinib
• Synonymes: 6-Amino-4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxyquinoline,6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, 4-[4-[(2-Pyridyl)methoxy]-3-chloroanilino]-6-amino-3-cyano-7-ethoxyquinoline
• Marque: TRC

Description

Applications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.
References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)

Propriétés chimiques

• Masse moléculaire: 445.9
• Formule: C₂₄H₂₀ClN₅O₂
• Couleur/Forme: Neat
• InChI: InChI=1S/C24H20ClN5O2/c1-2-31-23-11-21-18(10-20(23)27)24(15(12-26)13-29-21)30-16-6-7-22(19(25)9-16)32-14-17-5-3-4-8-28-17/h3-11,13H,2,14,27H2,1H3,(H,29,30)
• Code InChI: InChIKey=DIVNUTGTTIRPQA-UHFFFAOYSA-N
• SMILES: COc1ccc(CN)cc1OC