4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

CAS : 757251-39-1

Ref. TR-A609725

Informations sur le produit

• Nom: 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
• Synonymes: 4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide, 2-Pyridinecarboxamide, 4-(4-amino-3-fluorophenoxy)-N-methyl-, 4-(4-Amino-3-Fluorophenoxy)-N-Methylpicolinamide, 4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamide
• CAS: 757251-39-1

Description

Applications 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.
References Mross, K., et al.: Clin. Cancer Res., 18, 2658 (2012); Stiehl, J., et al. Process for Preparation of Regorafenib. PCT Int. Appl. 2011128261. Oct 20, 2011; Van Cutsem, E., et al.: J. Clin. Oncol., 30, 3502 (2012)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 261.25
• Formule: C₁₃H₁₂FN₃O₂
• Couleur/Forme: Dark Orange To Red Brown
• InChI: InChI=1S/C13H12FN3O2/c1-16-13(18)12-7-9(4-5-17-12)19-8-2-3-11(15)10(14)6-8/h2-7H,15H2,1H3,(H,16,18)
• Code InChI: InChIKey=ZQHJPIPGBODVTG-UHFFFAOYSA-N
• SMILES: CNC(=O)c1cc(Oc2ccc(N)c(F)c2)ccn1