Amphotericin B Methyl Ester 90%

CAS : 36148-89-7

Ref. TR-A634255

Informations sur le produit

• Nom: Amphotericin B Methyl Ester 90%
• Synonymes: methyl (1S,3R,4E,6E,8E,10E,12E,14E,16E,18S,19R,20R,21S,25R,27R,30R,31R,33S,35R,37S,38R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-25,27,30,31,33,35,37-heptahydroxy-18,19,20,21-tetramethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,12,14,16-heptaene-38-carboxylate, 14,39-Dioxabicyclo[33.3.1]nonatriacontane, amphotericin B deriv., Amphotericin B monomethyl ester, Amphotericin B, methyl ester, Methylamphotericin B, methyl (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate hydrochloride, methyl (1R,3S,5S,8S,9S,11R,15S,16S,17R,18S,25Z,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,8,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate

Description

Applications Amphotericin B Methyl Ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B Methyl Esterin is a cholesterol binding compound that showed inhibiton of human immunodeficiency virus type 1 (HIV-1).
References Waheed, A.A. et al.: J. Biol. Chem., 281, 28699 (2006); Waheed, A. et al.: J. Virol., 82, 9776 (2008); Waheed, A., et al.: J. Biol. Chem., 281, 28699 (2006)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 936.13
• Formule: C₄₉H₇₇NO₁₆
• Degré de pureté: >80%
• Couleur/Forme: Dark Yellow To Dark Orange
• InChI: InChI=1S/C49H77NO16/c1-29-19-17-15-13-11-9-7-8-10-12-14-16-18-20-37(65-48-46(59)44(50)45(58)33(5)64-48)26-41-43(47(60)62-6)40(56)28-49(61,66-41)27-36(53)24-39(55)38(54)22-21-34(51)23-35(52)25-42(57)63-32(4)31(3)30(29)2/h7-20,29-41,43-46,48,51-56,58-59,61H,21-28,50H2,1-6H3/b8-7+,11-9+,12-10+,15-13+,16-14+,19-17+,20-18+/t29-,30+,31+,32-,33+,34+,35+,36-,37-,38+,39+,40-,41-,43+,44-,45+,46-,48-,49+/m0/s1
• Code InChI: InChIKey=UAZIZEMIKKIBCA-TYVGYKFWSA-N
• SMILES: COC(=O)[C@@H]1[C@@H](O)C[C@@]2(O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)C[C@@H]1O2