Aprepitant-d4

CAS : 1133387-60-6

Ref. TR-A729803

Informations sur le produit

• Nom: Aprepitant-d4
• Synonymes: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl-d4)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend-d4, L 754030-d4, MK 0869-d4, MK 869-d4, ONO 7436-d4

Description

Applications Aprepitant-d4 is a labeled analogue of Aprepitant (A729800), A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Aprepitant-d4 is a potential treatment for chemotherapy induced nausea and vomiting.
References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 538.45
• Formule: C₂₃H₁₇D₄F₇N₄O₃
• Couleur/Forme: Neat
• InChI: InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1/i2D,3D,4D,5D
• Code InChI: InChIKey=ATALOFNDEOCMKK-NSVJKUEGSA-N
• SMILES: [2H]c1c([2H])c([C@H]2[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OCCN2Cc2n[nH]c(=O)[nH]2)c([2H])c([2H])c1F