Astemizole

CAS : 68844-77-9

Ref. TR-A790030

Informations sur le produit

• Nom: Astemizole
• Synonymes: Astemizole,1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-, Astemisan, Hismanal, Histamen, Histaminos, Histazol, Kelp, Laridal, Metodik, NSC 329963, Novo-Nastizol A, Paralergin, R 42512, R 43512, Retolen
• Marque: TRC

Description

Applications Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.
References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),

Propriétés chimiques

• Masse moléculaire: 458.57
• Formule: C₂₈H₃₁FN₄O
• Couleur/Forme: Neat
• InChI: InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
• Code InChI: InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N
• SMILES: COc1ccc(CCN2CCC(N=c3[nH]c4ccccc4n3Cc3ccc(F)cc3)CC2)cc1