Atazanavir-8-(N-methoxycarbonyl)-L-tert-leucine Ester

CAS : 2131010-71-2

Ref. TR-A790198

Informations sur le produit

• Nom: Atazanavir-8-(N-methoxycarbonyl)-L-tert-leucine Ester
• Synonymes: L-Valine, N-(methoxycarbonyl)-3-methyl-, (1S,2S)-2-[[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethyl-1-oxobutyl]amino]-1-[[2-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethyl-1-oxobutyl]-1-[[4-(2-pyridinyl)phenyl]methyl]hydrazinyl]methyl]-3-phenylpropyl ester (ACI), N-(Methoxycarbonyl)-3-methyl-L-valine (1S,2S)-2-[[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethyl-1-oxobutyl]amino]-1-[[2-[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethyl-1-oxobutyl]-1-[[4-(2-pyridinyl)phenyl]methyl]hydrazinyl]methyl]-3-phenylpropyl ester (ACI)
• Marque: TRC
• Description: Applications Atazanavir-8-(N-methoxycarbonyl)-L-tert-leucine Ester is an impurity of the drug Atazanavir (A790051). Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Newer research has been investigating the potential anticancer effects of atazanavirReferences Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),

Propriétés chimiques

• Masse moléculaire: 876.05
• Formule: C₄₆H₆₅N₇O₁₀
• Couleur/Forme: Neat
• InChI: InChI=1S/C46H65N7O10/c1-44(2,3)35(49-41(57)60-10)38(54)48-33(26-29-18-14-13-15-19-29)34(63-40(56)37(46(7,8)9)51-43(59)62-12)28-53(52-39(55)36(45(4,5)6)50-42(58)61-11)27-30-21-23-31(24-22-30)32-20-16-17-25-47-32/h13-25,33-37H,26-28H2,1-12H3,(H,48,54)(H,49,57)(H,50,58)(H,51,59)(H,52,55)/t33-,34-,35+,36+,37+/m0/s1
• Code InChI: InChIKey=XZYOTUXLJJSYCJ-QQVMGQLUSA-N
• SMILES: COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@H](CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)OC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C