2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one Hydrochloride

CAS : 135729-66-7

Ref. TR-A795310

Informations sur le produit

• Nom: 2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one Hydrochloride
• Synonymes: 2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one Monohydrochloride, 2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one Monohydrochloride, RS 42358-198
• Marque: TRC

Description

Applications 2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one Hydrochloride is an intermediate in the synthesis of Palonosteron (P165805), an serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
References Costall, B., et al.: Euro. J. Pharmacol., 234, 91 (1993);

Propriétés chimiques

• Masse moléculaire: 330.85
• Formule: C₁₉H₂₃ClN₂O
• Couleur/Forme: Neat
• InChI: InChI=1S/C19H22N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,11,13,17H,1,3,5,7-10,12H2;1H/t17-;/m0./s1
• Code InChI: InChIKey=PEMWWRCTBNOHCX-LMOVPXPDSA-N
• SMILES: Cl.O=c1c2cccc3c2c(cn1[C@H]1C[N@]2CC[C@@H]1CC2)CCC3