4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

CAS : 327036-89-5

Ref. TR-B285725

Informations sur le produit

• Nom: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
• Synonymes: GSK-3ß Inhibitor I, TDZD-8, 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-, Tdzd-8

Description

Applications Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).
References Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 222.26
• Formule: C₁₀H₁₀N₂O₂S
• Couleur/Forme: Neat
• InChI: InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
• Code InChI: InChIKey=JDSJDASOXWCHPN-UHFFFAOYSA-N
• SMILES: Cn1sc(=O)n(Cc2ccccc2)c1=O