24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506

CAS : 133941-75-0

Ref. TR-B415260

Informations sur le produit

• Nom: 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506
• Synonymes: 24,33-Bis-O-(tert-butyldimethylsilyl) Tacrolimus, (3S,4S,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-[(1E)-2-[(1R,3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 24,32-Bis-O-(tert-butyldimethylsilyl)-FK 506, 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(1E)-2-[(1R,3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S,4S,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-, 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxycyclohexyl]-1-methylethenyl]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-19-hydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4R*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-, FK 506 24,32-bis(tert-butyldimethylsilyl) ether

Description

Applications Protected form of FK-506 (Tacrolimus)
References Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., et al.: Brit. Med. J., 318, 1104 (1999),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 1032.54
• Formule: C₅₆H₉₇NO₁₂Si₂
• Couleur/Forme: Neat
• InChI: InChI=1S/C56H97NO12Si2/c1-20-23-41-29-35(2)28-36(3)30-47(64-14)50-48(65-15)32-38(5)56(62,67-50)51(59)52(60)57-27-22-21-24-42(57)53(61)66-49(39(6)45(34-43(41)58)69-71(18,19)55(10,11)12)37(4)31-40-25-26-44(46(33-40)63-13)68-70(16,17)54(7,8)9/h20,29,31,36,38-42,44-50,62H,1,21-28,30,32-34H2,2-19H3/b35-29-,37-31+/t36-,38+,39+,40-,41+,42-,44+,45-,46+,47-,48-,49+,50+,56+/m0/s1
• Code InChI: InChIKey=ZMQPVYFWZQHALN-JXPDAYSRSA-N
• SMILES: C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](OC)C3)[C@H](C)[C@@H](O[Si](C)(C)C(C)(C)C)CC1=O)[C@H](C)C[C@@H]2OC