BIX 01294 Trihydrochloride

CAS : 1392399-03-9

Ref. TR-B591600

Informations sur le produit

• Nom: BIX 01294 Trihydrochloride
• Synonymes: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine Trihydrochloride

Description

Applications BIX 01294 Trihydrochloride is a G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor that H3K9me2 chromatin levels modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
References Kubicek, S. et al.: Mol. Cell., 25, 473 (2007); Huangfu, D et al.: Nat. Biotechnol., 26, 795 (2008); Chang, Y. et al.: Bat. Struct. Mol. Biol., 16, 312 (2009);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 600.023
• Formule: C₂₈H₃₈N₆O₂ClH
• Couleur/Forme: Neat
• InChI: InChI=1S/C28H38N6O2.3ClH/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21;;;/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31);3*1H
• Code InChI: InChIKey=BZOWJAYUMMHCDW-UHFFFAOYSA-N
• SMILES: COc1cc2nc(N3CCCN(C)CC3)[nH]c(=NC3CCN(Cc4ccccc4)CC3)c2cc1OC.Cl.Cl.Cl.O