5-Bromo-1-(2-fluorophenyl)-2-pentanone

CAS : 1373350-56-1

Ref. TR-B687730

Informations sur le produit

• Nom: 5-Bromo-1-(2-fluorophenyl)-2-pentanone
• Synonymes: 5-bromo-1-(2-fluorophenyl)pentan-2-one

Description

Applications 5-Bromo-1-(2-fluorophenyl)-2-pentanone is an intermediate in the synthesis of Prasugrel (P701150). Prasugrel is a novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome.
References Von Beckerath, N., et al.: Circulation, 112, 2946 (2005), Jernberg, T., et al.: Eur. Heart J., 27, 1166 (2006), Farid, N., et al.: Drug Metab. Dispos., 35, 1096 (2007), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007), Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 49, 167 (2007), Wiviott, S., et al.: N. Engl. J. Med., 357, 2001 (2007),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 259.115
• Formule: C₁₁H₁₂BrFO
• Couleur/Forme: Neat
• InChI: InChI=1S/C11H12BrFO/c12-7-3-5-10(14)8-9-4-1-2-6-11(9)13/h1-2,4,6H,3,5,7-8H2
• Code InChI: InChIKey=JWOWGWXSDRIJDF-UHFFFAOYSA-N
• SMILES: O=C(CCCBr)Cc1ccccc1F