(R)-t-Butyl 2-((4-methyl-1-(1-methylcyclopropyl)-1-oxopentan-2-yl)amino)acetate (>85%)

CAS : 2177287-68-0

Ref. TR-B809473

Informations sur le produit

• Nom: (R)-t-Butyl 2-((4-methyl-1-(1-methylcyclopropyl)-1-oxopentan-2-yl)amino)acetate (>85%)

Description

Applications (R)-t-Butyl 2-((4-methyl-1-(1-methylcyclopropyl)-1-oxopentan-2-yl)amino)acetate is an intermediate in synthesizing (R)-2-Amino-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt (A605100), an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 271.35
• Formule: C₁₄H₂₅NO₄
• Degré de pureté: >85%
• Couleur/Forme: Neat
• InChI: InChI=1S/C14H25NO4/c1-9(2)7-10(11(16)14(6)8-18-14)15-12(17)19-13(3,4)5/h9-10H,7-8H2,1-6H3,(H,15,17)/t10-,14-/m1/s1
• Code InChI: InChIKey=FBISRXJSJBLOHX-UHFFFAOYSA-N
• SMILES: CC(=O)C(C(N)=O)c1ccccc1