Informations sur le produit
Nom :
C646
Synonymes :
- 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid
- C 646
- Benzoic acid, 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-
- 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
Description :
Applications C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients.
References Gao, X., et al.: Zhang, X., et al.: PLoS One, 8, e55481 (2013); Zhonghua Shiyan Waike Zazhi, 30, 1177 (2013); Bowers, E.M., et al.: Chem. Biol., 17, 471 (2010)
Avis:
Nos produits sont destinés uniquement à un usage en laboratoire. Pour tout autre usage, veuillez nous contacter.
Marque:
TRC
Stockage à long terme :
Notes :
Propriétés chimiques
Masse moléculaire :
445.42
Formule :
C24H19N3O6
Couleur/Forme :
Dark Orange Solid
InChI :
InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
Code InChI :
InChIKey=GEFQWZLICWMTKF-ANLVUFKYSA-N
SMILES :
C[C@@H](N)[C@H](O)c1ccc(O)c(O)c1
MDL:
Point de fusion :
Point d'ébullition :
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Merck :
Code SH :
