Cerivastatin lactone

CAS : 158878-47-8

Ref. TR-C277005

Informations sur le produit

• Nom: Cerivastatin lactone
• Synonymes: [4R-[4a,6ß(E)]]-6-[2-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one, (4R,6S)-6-((E)-2-(4-(4-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one, (4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one

Description

Stability Hygroscopic
Applications Cerivastatin lactone is a metabolite of a competitive inhibitor of HMG-CoA reductase, Cerivastatin (C277000). Cerivastatin lactone shows inhibitory effects on CYP3A4/5 activity.
References Ness, C.G., et al.: Arch. Biochem. Biophys., 325, 242 (1996); Steinke, W., et al.: Japan. Pharmacol. Ther., 24, Suppl. 9, S1217 (1996); Sakaeda, T., et. al.: Pharmaceut. Res., 23, 506 (2006)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 441.53
• Formule: C₂₆H₃₂FNO₄
• Couleur/Forme: Neat
• InChI: InChI=1S/C26H32FNO4/c1-15(2)25-21(11-10-20-12-19(29)13-23(30)32-20)24(17-6-8-18(27)9-7-17)22(14-31-5)26(28-25)16(3)4/h6-11,15-16,19-20,29H,12-14H2,1-5H3/b11-10+/t19-,20-/m1/s1
• Code InChI: InChIKey=MCBZSKZRUIWKPM-ANMDKAQQSA-N
• SMILES: COCc1c(C(C)C)nc(C(C)C)c(/C=C/[C@@H]2C[C@@H](O)CC(=O)O2)c1-c1ccc(F)cc1