Chidamide

CAS : 1616493-44-7

Ref. TR-C291980

Informations sur le produit

• Nom: Chidamide
• Synonymes: N-(2-Amino-4-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propenyl]amino]methyl]-benzamide, N-(2-Amino-4-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide, CS 055, Epidaza, HBI 8000, N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide, Tucidinostat, Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-

Description

Applications Chidamide is a newly designed histone deacetylase inhibitor that induces an antitumor effect in various cancer by increasing the acetylation levels of histone H3 and decrease histone deacetylase (HDAC) activity, induces apoptosis. Also, it is a potential utility of Chidamide for the treatment of Myelodysplastic syndromes.
References Liu, Z., et al.: Biomed. Pharmacother., 83, 1032-1027 (2016)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 390.41
• Formule: C₂₂H₁₉FN₄O₂
• Couleur/Forme: Neat
• InChI: InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+
• Code InChI: InChIKey=SZMJVTADHFNAIS-BJMVGYQFSA-N
• SMILES: Nc1cc(F)ccc1NC(=O)c1ccc(CNC(=O)/C=C/c2cccnc2)cc1