4-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid

CAS : 402849-27-8

Ref. TR-C365540

Informations sur le produit

• Nom: 4-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid
• Synonymes: Benzoic acid, 4-chloro-, 2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide, 4-Chloro-N'-(4-chlorobenzoyl)-N-(4-methoxyphenyl)benzohydrazide, Indometacin dibenzylate
• Marque: TRC
• Description: Applications An impurity of the anti-inflammatory drug indomnethacin (I641000). Indomethacin inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)

Propriétés chimiques

• Masse moléculaire: 415.27
• Formule: C₂₁H₁₆Cl₂N₂O₃
• Couleur/Forme: Neat
• InChI: InChI=1S/C21H16Cl2N2O3/c1-28-19-12-10-18(11-13-19)25(21(27)15-4-8-17(23)9-5-15)24-20(26)14-2-6-16(22)7-3-14/h2-13H,1H3,(H,24,26)
• Code InChI: InChIKey=GSKPJTLOCASRRI-UHFFFAOYSA-N
• SMILES: COc1ccc(N(NC(=O)c2ccc(Cl)cc2)C(=O)c2ccc(Cl)cc2)cc1