(3S)-4-Chloro-3-hydroxybutyronitrile

CAS : 127913-44-4

Ref. TR-C366605

Informations sur le produit

• Nom: (3S)-4-Chloro-3-hydroxybutyronitrile
• Synonymes: (3S)-4-Chloro-3-hydroxybutanenitrile, (S)-4-Chloro-3-hydroxybutanenitrile, (S)-(-)-4-Chloro-3-hydroxybutyronitrile, (S)-4-Chloro-3-hydroxybutyronitrile, S-(-)-4-chloro-3-hydorxy butyronitrile, (3S)-4-chloro-3-hydorxybutyronitrile, (3R)-4-chloro-3-hydroxybutanenitrile, (3S)-4-chloro-3-hydroxybutanenitrile
• CAS: 127913-44-4

Description

Applications (3S)-4-Chloro-3-hydroxybutyronitrile is used in various organic precursor syntheses. It is used in the synthesis of hydroxypyrrolidinones to by used as carbapenem precursors. Also used in the preparation of atorvastatin (A791750) precursors. Impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Kanno, O. et al.: Hetero., 53, 173 (2000); Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006); Jiang, C. et al.: Lett. Org. Chem., 9, 520 (2012);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 119.55
• Formule: C₄H₆ClNO
• Couleur/Forme: Neat
• InChI: InChI=1S/C4H9ClO/c1-2-4(6)3-5/h4,6H,2-3H2,1H3/t4-/m0/s1
• Code InChI: InChIKey=VNBFUGOVQMFIRN-BYPYZUCNSA-N
• SMILES: N#CC[C@H](O)CCl