2-Chloro-5-nitro-N-4-pyridinylbenzamide

CAS : 313516-66-4

Ref. TR-C374760

Informations sur le produit

• Nom: 2-Chloro-5-nitro-N-4-pyridinylbenzamide
• Synonymes: T 0070907
• Marque: TRC

Description

Applications A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
References Lee, G., et al: J. Biol. Chem., 277, 19649 (2003), Schaefer, K.L., et al: Cancer Res., 65, 2251 (2005), Masuda, T., et al.: Clin. Cancer Res., 11, 4012 (2005), Raikwar, H.P., et al.: J. Neuroimmunol., 167, 99 (2005)

Propriétés chimiques

• Masse moléculaire: 277.66
• Formule: C₁₂H₈ClN₃O₃
• Couleur/Forme: Neat
• InChI: InChI=1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
• SMILES: O=C(Nc1ccncc1)c1cc([N+](=O)[O-])ccc1Cl