Cidofovir Hydrate

CAS : 113852-37-2

Ref. TR-C433500

Informations sur le produit

• Nom: Cidofovir Hydrate
• Synonymes: Cidofovir, P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, (S)-HPMPC, GS-504, Vistide, (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine, (S)-Hpmpc, ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid, 1-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine, 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine, Cidofovir (anhydrous), Cidofovir monophosphate, Cidovir, Gs 0504, Hpmpc, Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, (S)-, Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, Phosphonic acid, [[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, Unii-768M1V522C, {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid

Description

Applications An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).
References Rahal, F.M. et al.: Ann. Internal Med., 125, 98 (1996); Johnson, J.A. et al.: Antimicrob. Agents Chemother., 43, 1190 (1999); Ho, H.T. et al.: Mol. Pharmacol., 41, 197 (1992);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 279.19
• Formule: C₈H₁₄N₃O₆P
• Couleur/Forme: White Powder
• InChI: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
• SMILES: N=c1ccn(C[C@@H](CO)OCP(=O)([O-])O)c([O-])n1.[Na+].[Na+]