Citicoline Sodium Salt

CAS : 33818-15-4

Ref. TR-C508050

Informations sur le produit

• Nom: Citicoline Sodium Salt
• Synonymes: Acticolin, Brassel, Cebroton, Cidifos, Flussorex, Gerolin, Logan, Neurotron, Sinkron, Cytidine 5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester, hydroxide, inner salt, monosodium salt, Cytidine 5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester, inner salt, monosodium salt (9CI), CerAxon, Citicoline sodium, IP 302 sodium, Strolin,Choline, hydroxide, monoester with cytidine 5'-(trihydrogen pyrophosphate), inner salt
• Marque: TRC

Description

Applications Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. Neuroprotective product. Citicholine exhibits protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Recently showed efficacy against dementia when given with AchEIs (Acetylcholinesterase inhibitor) (1). Depicts Neuroprotective, acnticonvulsant activity and sedative effect at a dose of 150mg/kg in rats. (2). Showed protection against aluminum induced cognitive impairment in rats reducing elevated glutamate level, oxidative stress and NO overproduction in the hippocampus.
References Castagna A, et al. Clin Drug Investig. 2016 Sep 1 Abdolmaleki A, et al. 2016. Eur J Pharmacol. Oct 15;789:275-9Abdel-Zaher AO et al. Toxicol Ind Health. 2016 May 13

Propriétés chimiques

• Masse moléculaire: 510.31
• Formule: C₁₄H₂₅N₄O₁₁P₂·Na
• Couleur/Forme: Neat
• InChI: InChI=1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9-,11-,12-,13-;/m1./s1
• SMILES: C[N+](C)(C)CCOP(=O)(OC[C@H]1O[C@@H](n2ccc(=N)nc2[O-])[C@H](O)[C@@H]1O)OP(=O)([O-])O.[Na+]