Clofarabine

CAS : 123318-82-1

Ref. TR-C586890

Informations sur le produit

• Nom: Clofarabine
• Synonymes: Clofarex, Clolar, Evoltra,Clofarabine, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine, 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine, 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE, 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-, (2R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol, 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin, 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine, Clolar, 2-Chloro-9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-9H-Purin-6-Amine, 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine, CAFDA, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine, 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol, 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine

Description

Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 303.68
• Formule: C₁₀H₁₁ClFN₅O₃
• Couleur/Forme: Neat
• InChI: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
• Code InChI: InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N
• SMILES: Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F