Colchicine Methanethiosulfonate

CAS : 1217821-52-7

Ref. TR-C640030

Informations sur le produit

• Nom: Colchicine Methanethiosulfonate
• Synonymes: 3-Methylsulfonylsulfanyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]propanamide
• Marque: TRC
• Description: Applications The methanethiosulfonate derfivative of Colchicine (C640000), an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

Propriétés chimiques

• Masse moléculaire: 511.61
• Formule: C₂₂H₂₅NO₆·CH₄O₂S₂
• Couleur/Forme: Neat
• InChI: InChI=1S/C22H25NO6.CH4O2S2/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16;1-5(2,3)4/h7,9-11,16H,6,8H2,1-5H3,(H,23,24);1H3,(H,2,3,4)/t16-;/m0./s1
• Code InChI: InChIKey=KZMCZFBQMMHSRF-KRWDZBQOSA-N
• SMILES: COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(=O)CCSS(C)(=O)=O)CC2