Curcumin-d6

CAS : 1246833-26-0

Ref. TR-C838502

Informations sur le produit

• Nom: Curcumin-d6
• Synonymes: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6, (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6, C Yellow 15-d6, C.I. 75300-d6, Curcuma-d6, Curcumine-d6, Diferuloylmethane-d6, Haidr-d6, Halad-d6, Haldar-d6, Ukon-d6
• CAS: 1246833-26-0

Description

Applications Labelled Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 374.42
• Formule: C₂₁H₁₄D₆O₆
• Couleur/Forme: Orange to Dark Orange Solid
• InChI: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+/i1D3,2D3
• Code InChI: InChIKey=VFLDPWHFBUODDF-BQWNYRPNSA-N
• SMILES: [2H]C([2H])([2H])Oc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC([2H])([2H])[2H])c2)ccc1O