[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-κN,κN') Diiodoplatinum

CAS : 66845-32-7

Ref. TR-C984525

Informations sur le produit

• Nom: [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-κN,κN') Diiodoplatinum
• Synonymes: (trans-1R,2R-1,2-Diaminocyclohexane)diiodoplatinum, (trans-R,R-1,2-Diaminocyclohexane)diiodoplatinum, (trans-R,R-Cyclohexane-1,2-diamine)diiodoplatinum, Diiodo(trans-l-1,2-cyclohexanediamine)platinum, NSC 290127,(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-?N,?N']diiodoplatinum, (1R-trans)-1,2-Cyclohexanediamine Platinum Complex, [SP-4-2-(1R-trans)]-(1,2-cyclohexanediamine-N,N')diiodoplatinum, USP Oxaliplatin Related Compound

Description

Applications [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-κN,κN')diiodoplatinum is a potential antitumor agent. Impurity of Oxiplatin (O845075), third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y. et al.: Biomed. Pharmacther., 43, 261 (1989); Noji, M. et al.: J. Med. Chem., 24, 508 (1981); Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 563.08
• Formule: C₆H₁₄I₂N₂Pt
• Couleur/Forme: Neat
• InChI: InChI=1S/C6H14N2.2HI.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2/t5-,6-;;;/m1.../s1
• Code InChI: InChIKey=AEAVNKNQJBFMCW-SKSSAGQDSA-L