Trametinib-13C6

CAS : 871700-17-3

Ref. TR-C988931

Informations sur le produit

• Nom: Trametinib-13C6
• Synonymes: N-[5-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl](1,2,3,4,5,6-13C6)cyclohexa-1,3,5-trien-1-yl]acetamide, Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-, G 02442104, Gsk 212, Gsk-1120212, Jtp 74057, Mekinist, N-[3-[3-Cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide, Trametinib
• CAS: 871700-17-3

Description

Applications Trametinib-13C6 is the labelled compound form of Trametinib (C988930), which is used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor and potent MEK inhibitor.
References Ercan, D., et al.: Canc. Disc., 2, 934 (2012); Mackiewicz-Wysocka, M., et al.: Exp. Opin. Investig. Drugs., 22, 181 (2013);

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 621.351
• Formule: C₆C₂₀H₂₃FIN₅O₄
• Couleur/Forme: Neat
• InChI: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)/i4+1,5+1,6+1,12+1,16+1,18+1
• Code InChI: InChIKey=LIRYPHYGHXZJBZ-YGELHQHLSA-N
• SMILES: CC(=O)N[13c]1[13cH][13cH][13cH][13c](-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)[13cH]1