Dibenzyloxy Tenofovir

CAS : 848944-60-5

Ref. TR-D018510

Informations sur le produit

• Nom: Dibenzyloxy Tenofovir
• Synonymes: 9-[(2R)-2-[bis(phenylmethoxy)phosphorylmethoxy]propyl]purin-6-amine

Description

Applications Dibenzyloxy Tenofovir is an intermediate in the synthesis of Tenofovir Dibenzyloxy Isopropyl Carbamate (T018545); Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 467.457
• Formule: C₂₃H₂₆N₅O₄P
• Couleur/Forme: Neat
• InChI: InChI=1S/C23H26N5O4P/c1-18(12-28-16-27-21-22(24)25-15-26-23(21)28)30-17-33(29,31-13-19-8-4-2-5-9-19)32-14-20-10-6-3-7-11-20/h2-11,15-16,18H,12-14,17H2,1H3,(H2,24,25,26)/t18-/m1/s1
• Code InChI: InChIKey=KVVVIYQPQFZDJU-GOSISDBHSA-N
• SMILES: C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(OCc1ccccc1)OCc1ccccc1