DAMGO

CAS : 78123-71-4

Ref. TR-D134600

Informations sur le produit

• Nom: DAMGO
• Synonymes: [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin, 158: PN: US20030176421 PAGE: 54-55 Caimed Protein TFA Salt, 3: PN: WO2009046859 PAGE: 98 Claimed Protein DAGO TFA Salt, DAGOL TFA Salt, DAMGE TFA Salt, DAMGO TFA Salt, DAMPGO TFA Salt, H-Tyr-D-Ala(Me)Phe-NH-CH2-OH NIH 10891 TFA Salt, RX 783006 TFA Salt, Tyr-D-Ala-Gly-(methyl)Phe-Gly-ol TFA Salt, Tyr-D-Ala-Gly-MePhe-Gly-ol TFA Salt, Tyr-D-Ala-Gly-MePhe-NH-(CH2)2OH TFA Salt, Tyr-D-Ala-Gly-N-methylphenylalanine-glycinol TFA Salt, [D-Ala(2),N-methyl-Phe(4),Gly(5)-ol]-enkephalin TFA Salt, Enkephalin, ala(2)-mephe(4)-gly(5)-, (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin, 2-Ala-4-mephe-5-gly-enkephalin, Ala(2)-mephe(4)-gly-ol(5) enkephalin, Dago, Damge, Dagol, Enkephalin, Ala(2)-MePhe(4)-Gly-ol(5)-, Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-, Rx 783006, Tyr-ala-gly-(nme)phe-gly-ol, Glyol, L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl-, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl-L-phenylalaninamide

Description

Stability Hygroscopic
Applications DAMGO is an opioid receptor agonist (1,2). DAMGO can be used to investigate the analgesic mechanism of opioids. It has been shown that DAMGO can modulate the two-pore domain K(+) channels in the substantia gelatinosa neurons (3).
References (1) Talmont, F. et al.: Peptide., 55, 79 (2014) (2) Trigub, M. et al.: Bull. Exp. Biol. Med., 156, 778 (2014) (3) Cho, P. S., et al.: Korean J Physiol Pharmacol. 20, 525 (2016)

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 513.5911402
• Formule: C₂₆H₃₅N₅O₆•x(C₂HF₃O₂)
• Couleur/Forme: Neat
• InChI: InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
• Code InChI: InChIKey=HPZJMUBDEAMBFI-WTNAPCKOSA-N
• SMILES: C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO